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Targetmknk1 high atp
LigandBDBM333397
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50 42.0±n/a nM
Citation Eis, KPühler, FZorn, LScholz, ALienau, PGnoth, MJBömer, UGünther, JFanghänel, JKorr, D Substituted aminoimidazopyridazines US Patent US9730929 Publication Date 8/15/2017  Article
More Info.:Get all data from this article,  Assay Method
 
mknk1 high atp
Name:MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1
Type:Serine/threonine-protein kinase
Mol. Mass.:51342.85
Organism:Homo sapiens (Human)
Description:Q9BUB5
Residue:465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM333397
NameBDBM333397
Synonyms:2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl](cyclopropyl)amino}-1-(4-fluorophenyl)ethanol | US9730929, Example 18
TypeSmall organic molecule
Emp. Form.C25H21FN4O2
Mol. Mass.428.4582
SMILESOC(CN(C1CC1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccc(F)cc1 |w:1.0|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a