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Targetmknk1 high atp
LigandBDBM214648
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50 250±n/a nM
Citation Eis, KPühler, FZorn, LScholz, ALienau, PGnoth, MJBömer, UGünther, JFanghänel, JKorr, D Substituted aminoimidazopyridazines US Patent US9730929 Publication Date 8/15/2017
More Info.:Get all data from this article,  Assay Method
 
mknk1 high atp
Name:MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1
Type:Serine/threonine-protein kinase
Mol. Mass.:51342.85
Organism:Homo sapiens (Human)
Description:Q9BUB5
Residue:465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
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  Blast E-value cutoff:
BDBM214648
NameBDBM214648
Synonyms:US9284319, R6 | US9730929, Example R6 | US9783543, R6
TypeSmall organic molecule
Emp. Form.C21H17N5O
Mol. Mass.355.3926
SMILESC(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Structure
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n/a