Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM334290
Substrate
n/a
Meas. Tech.
In Vitro Assay
EC50
6500±n/a nM
Citation
 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH Cinnoline derivatives useful as CB-1 receptor inverse agonists US Patent  US9732061 Publication Date 8/15/2017 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM334290
Synonyms:
US9732061, Compound 12
Type:
Small organic molecule
Emp. Form.:
C34H30Cl2N4O2
Mol. Mass.:
597.534
SMILES:
OC(=O)c1cccc(CN2CCC(CC2)Nc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1
Structure:
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