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TargetMitogen-activated protein kinase 12 (p38MAPgamma)
LigandBDBM334327
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
IC50 50.0±n/a nM
Citation Frickel, FFyfe, MCMeghani, PThom, SM Kinase inhibitors US Patent US9732063 Publication Date 8/15/2017
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 12 (p38MAPgamma)
Name:p38 delta/gamma
Synonyms:MAP kinase p38 gamma | Mitogen-activated protein kinase 12 (MAPK12 p38 gamma) | Mitogen-activated protein kinase 12 (p38 gamma) | Mitogen-activated protein kinase p38 gamma (p38 MAPKγ)
Type:Protein
Mol. Mass.:41938.69
Organism:Homo sapiens (Human)
Description:P53778
Residue:367
Sequence:
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETPL
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  Blast E-value cutoff:
BDBM334327
NameBDBM334327
Synonyms:3-(4-((4-(3-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate | US9732063, Example 11
TypeSmall organic molecule
Emp. Form.C35H33N7O5S
Mol. Mass.663.745
SMILESCC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(OS(C)(=O)=O)c4)n3)c3ccccc23)n(n1)-c1ccc(C)cc1
Structure
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