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Target
Glycogen synthase kinase-3 alpha
Ligand
BDBM334340
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
117±n/a nM
Citation
 Frickel, F; Fyfe, MC; Meghani, P; Thom, SM Kinase inhibitors US Patent  US9732063 Publication Date 8/15/2017 
Target
Name:
Glycogen synthase kinase-3 alpha
Synonyms:
GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha)
Type:
Enzyme
Mol. Mass.:
50991.79
Organism:
Homo sapiens (Human)
Description:
P49840
Residue:
483
Sequence:
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
  
Inhibitor
Name:
BDBM334340
Synonyms:
1-(2,3-Dichloro-4-((2-((3-(cyclopropylsulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea | US9732063, Example 24
Type:
Small organic molecule
Emp. Form.:
C33H31Cl2N7O4S
Mol. Mass.:
692.615
SMILES:
CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(c4)S(=O)(=O)C4CC4)n3)c(Cl)c2Cl)n(n1)-c1ccc(C)cc1
Structure:
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