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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM199484
Substrate
n/a
Meas. Tech.
Inhibition of Ca Flux Activity of 5-HT3 In Vitro Assay
Temperature
298.15±n/a K
IC50
0.680±n/a nM
Comments
extracted
Citation
 Hitchcock, S; Monenschein, H; Reichard, H; Sun, H; Kikuchi, S; Macklin, T; Hopkins, M 5-HT3 receptor antagonists US Patent  US9670229 Publication Date 6/6/2017 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM199484
Synonyms:
(1r,5s,7s)-9-methyl-d3-3-oxa-9-azabicyclo [3.3.1]nonan-7-yl 1-(pyridin-2-yl)-1h- indole-3-carboxylate, 2,2,2-trifluoroacetate | US10125145, Cpd. No. 9 | US9670229, 9
Type:
Small organic molecule
Emp. Form.:
C20H22N4O3
Mol. Mass.:
366.4137
SMILES:
Cn1cc(cn1)-n1cc(C(=O)OC2CC3COCC(C2)N3)c2ccccc12 |TLB:11:12:20:15.16.17|
Structure:
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