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TargetAurora kinase B
LigandBDBM12984
Substrate/CompetitorCHOCKtide
Meas. Tech.Kinase SPA Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 99±n/a nM
Citation Fancelli, DMoll, JVarasi, MBravo, RArtico, RBerta, DBindi, SCameron, ACandiani, ICappella, PCarpinelli, PCroci, WForte, BGiorgini, MLKlapwijk, JMarsiglio, APesenti, ERocchetti, MRoletto, FSeverino, DSoncini, CStorici, PTonani, RZugnoni, PVianello, P 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent aurora kinase inhibitor with a favorable antitumor kinase inhibition profile. J Med Chem49:7247-51 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIM-1 | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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  Blast E-value cutoff:
BDBM12984
NameBDBM12984
Synonyms:4-(4-methylpiperazin-1-yl)-N-{5-[(2R)-2-phenylpropanoyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}benzamide | 5-Amido-pyrrolopyrazole 9c | CHEMBL427787
TypeSmall organic molecule
Emp. Form.C26H30N6O2
Mol. Mass.458.5554
SMILESC[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
CHOCKtide
Name:CHOCKtide
Synonyms:n/a
Type:Peptide
Mol. Mass.:889.06
Organism:n/a
Description:n/a
Residue:7
Sequence:
LRRWSLG