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Target
Cathepsin D
Ligand
BDBM335467
Substrate
n/a
Meas. Tech.
Cathepsin-D Assay
Ki
>9400±n/a nM
Citation
 Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W C2-carbocyclic iminothiazine dioxides as BACE inhibitors, compositions, and their use US Patent  US9732088 Publication Date 8/15/2017 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM335467
Synonyms:
(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- fluoro-1,7-naphthyridin-8- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide | US9732088, Example 26
Type:
Small organic molecule
Emp. Form.:
C22H22F2N6O2S
Mol. Mass.:
472.511
SMILES:
C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(F)cnc23)ncc1F |r,c:13|
Structure:
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