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Target
Flap endonuclease 1
Ligand
BDBM167083
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
2.80±n/a nM
Citation
 Eccles, W; Fitzgerald, AE; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Liu, J; Mani, NS; McClure, KJ; Meduna, SP; Rosen, MD FLAP modulators US Patent  US9732093 Publication Date 8/15/2017 
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM167083
Synonyms:
US9073876, 168 | US9732093, Compound 168
Type:
Small organic molecule
Emp. Form.:
C21H23FN6O
Mol. Mass.:
394.4453
SMILES:
CC(C)c1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)nc2)nc(N)n1
Structure:
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