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Target
Complement factor D
Ligand
BDBM335514
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
5500±n/a nM
Citation
 Gadhachanda, VR; Pais, G; Hashimoto, A; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS; Wiles, JA Ether compounds for treatment of complement mediated disorders US Patent  US9732104 Publication Date 8/15/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM335514
Synonyms:
(2S,4R)-1-(2-(3-acetyl-6- ((tricyclo[8.2.2.24,7]hex- adeca-4,6,10,12,13,15- hexaen-5-ylmethyl)oxy)-1H- indol-1-yl)acetyl)-N-(3- chloro-2-fluorobenzyl)-4- fluoropyrrolidine-2- carboxamide | US10550140, Compound 6 | US9732104, Compound 6
Type:
Small organic molecule
Emp. Form.:
C41H38ClF2N3O4
Mol. Mass.:
710.208
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(OCc3cc4CCc5ccc(CCc3cc4)cc5)ccc12 |r|
Structure:
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