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Target
Complement factor D
Ligand
BDBM335533
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<1000±n/a nM
Citation
 Gadhachanda, VR; Pais, G; Hashimoto, A; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS; Wiles, JA Ether compounds for treatment of complement mediated disorders US Patent  US9732104 Publication Date 8/15/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM335533
Synonyms:
1,1'-(((3-acetyl-1-(2- ((2S,4R)-2-(3-chloro-2- fluorobenzylcarbamoyl)- 4-fluoropyrrolidin-1-yl)- 2-oxoethyl)-1H-indol-6- yloxy)methyl)phosph- oryl)bis(oxy)bis(2- methylpropane-1,1-diyl) dipropionate | US9732104, Compound 23
Type:
Small organic molecule
Emp. Form.:
C39H49ClF2N3O11P
Mol. Mass.:
840.243
SMILES:
CCC(=O)OC(OP(=O)(COc1ccc2c(cn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(C)=O)OC(OC(=O)CC)C(C)C)C(C)C |r,w:5.57,45.54|
Structure:
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