Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM335535
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<1000±n/a nM
Citation
 Gadhachanda, VR; Pais, G; Hashimoto, A; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS; Wiles, JA Ether compounds for treatment of complement mediated disorders US Patent  US9732104 Publication Date 8/15/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM335535
Synonyms:
(3-acetyl-1-(2-((2S,4R)-4- fluoro-2-(3-fluoro-4- (trifluoromethoxy)phen- ylcarbamoyl)pyrrolidin-1- yl)-2-oxoethyl)-1H-indol- 6-yloxy)methylphosphonic acid | US10550140, Compound 25 | US9732104, Compound 25
Type:
Small organic molecule
Emp. Form.:
C25H23F5N3O8P
Mol. Mass.:
619.4312
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2ccc(OC(F)(F)F)c(F)c2)c2cc(OCP(O)(O)=O)ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: