Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM333411
Substrate
n/a
Meas. Tech.
BRD4 AlphaScreen Assay
IC50
550±n/a nM
Citation
 Yue, EW; Combs, AP; Buesking, AW Bicyclic heterocycles as bet protein inhibitors US Patent  US9737516 Publication Date 8/22/2017 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Homo sapiens (Human)
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM333411
Synonyms:
5-(2,4-Difluorophenoxy)-1,3-dimethyl-6-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one | US9737516, Example 7
Type:
Small organic molecule
Emp. Form.:
C23H18F2N4O3
Mol. Mass.:
436.4108
SMILES:
Cn1c2cc(Oc3ccc(F)cc3F)c(cc2n(C)c1=O)-c1cn(C)c(=O)c2[nH]ccc12
Structure:
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