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TargetBromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)
LigandBDBM333420
Substrate/Competitorn/a
Meas. Tech.BRD4 AlphaScreen Assay
IC50<100±n/a nM
Citation Yue, EWCombs, APBuesking, AW Bicyclic heterocycles as bet protein inhibitors US Patent US9737516 Publication Date 8/22/2017
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)
Name:Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)
Synonyms:Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2
Type:Protein
Mol. Mass.:8564.63
Organism:Homo sapiens (Human)
Description:BD2 (368-440 aa) of O60885
Residue:73
Sequence:
KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFS
NCYKYNPPDHEVV
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BDBM333420
NameBDBM333420
Synonyms:4-[5-(Cyclobutylmethoxy)-1-benzyl-1H-benzimidazol-6-yl]-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one and 4-[6-(Cyclobutylmethoxy)-1-benzyl-1H-benzimidazol-5-yl]-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one | US9737516, Example 16 | US9737516, Example 17
TypeSmall organic molecule
Emp. Form.C27H26N4O2
Mol. Mass.438.5209
SMILESCn1cc(-c2cc3n(Cc4ccccc4)cnc3cc2OCC2CCC2)c2cc[nH]c2c1=O
Structure
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