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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50424850
Substrate
n/a
Meas. Tech.
Biochemical Deacetylation Assay
IC50
7000±n/a nM
Citation
 Kazantsev, AG; Thompson, LM; Abagyan, R; Casale, M Small molecule activators of NRF2 pathway US Patent  US9737525 Publication Date 8/22/2017 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50424850
Synonyms:
CHEMBL2315467 | US9737525, Compound MIND4-19
Type:
Small organic molecule
Emp. Form.:
C22H19N3OS
Mol. Mass.:
373.471
SMILES:
C(Oc1ccccc1)c1nnc(SCc2ccccc2)n1-c1ccccc1
Structure:
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