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TargetAP2-associated protein kinase 1 (AAK1)
LigandBDBM335583
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50 550±n/a nM
Citation Dzierba, CDDasgupta, BMacor, JEBronson, JJRajamani, RKarageorge, GN Pyrrolotriazine kinase inhibitors US Patent US9737542 Publication Date 8/22/2017  Article
More Info.:Get all data from this article,  Assay Method
 
AP2-associated protein kinase 1 (AAK1)
Name:AP2-associated protein kinase 1
Synonyms:AAK1 | Adaptor-associated kinase 1 | KIAA1048
Type:PROTEIN
Mol. Mass.:103884.23
Organism:Homo sapiens (Human)
Description:ChEMBL_774569
Residue:961
Sequence:
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM335583
NameBDBM335583
Synonyms:N-(3-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)phenyl)-5-((hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine | US9737542, Example 26
TypeSmall organic molecule
Emp. Form.C24H26N8S
Mol. Mass.458.582
SMILESC(N1CC2CNCC2C1)c1ccn2ncnc(Nc3cccc(c3)-c3nnc(s3)C3CC3)c12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a