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Target
Mitogen-activated protein kinase 14
Ligand
BDBM13350
Substrate
myelin basic protein
Meas. Tech.
p38alpha Kinase Enzyme Assay
pH
7.4±n/a
Temperature
295.15±n/a K
IC50
162000±n/a nM
Citation
 Gill, AL; Frederickson, M; Cleasby, A; Woodhead, SJ; Carr, MG; Woodhead, AJ; Walker, MT; Congreve, MS; Devine, LA; Tisi, D; O'Reilly, M; Seavers, LC; Davis, DJ; Curry, J; Anthony, R; Padova, A; Murray, CW; Carr, RA; Jhoti, H Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation. J Med Chem 48:414-26 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM13350
Synonyms:
3-fluoro-N-(1H-indol-5-yl)-5-(morpholin-4-yl)benzamide | 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide | Indole derived fragment based inhibitor 22
Type:
Small organic molecule
Emp. Form.:
C19H18FN3O2
Mol. Mass.:
339.3635
SMILES:
Fc1cc(cc(c1)C(=O)Nc1ccc2[nH]ccc2c1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
myelin basic protein
Synonyms:
myelin A1 protein
Type:
Other Protein Type
Mol. Mass.:
4541.90
Organism:
Oryctolagus cuniculus (rabbit)
Description:
n/a
Residue:
42
Sequence:
FGSDRGAPKRGSGKDHAARTTHYGSLPQKSGHRPQDENPVVH