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TargetProstaglandin E2 receptor EP3 subtype
LigandBDBM335699
Substrate/Competitorn/a
Meas. Tech.Radioligand SPA Binding Assay
Ki 7.20±n/a nM
Citation Bahnck, KCanterbury, DEdmonds, DJFutatsugi, KLee, ECMenhaji-Klotz, EPolivkova, JStanton, RV Antagonists of prostaglandin EP3 receptor US Patent US9738626 Publication Date 8/22/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor EP3 subtype
Name:Prostaglandin E2 receptor
Synonyms:PGE receptor, EP3 subtype | PGE2-R | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:Enzyme
Mol. Mass.:43335.03
Organism:Homo sapiens (Human)
Description:P43115
Residue:390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER
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BDBM335699
NameBDBM335699
Synonyms:(R)-3-(3-Methyl-2-oxopiperidin-3-yl)-6-(5-methylquinolin-7-yl)pyridin-2(1H)-one | US9738626, 2 (free base and TFA salt)
TypeSmall organic molecule
Emp. Form.C21H21N3O2
Mol. Mass.347.4103
SMILESCc1cc(cc2ncccc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Structure
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