Reaction Details Report a problem with these data
Target
Catenin beta-1 [138-686]
Ligand
BDBM213752
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
Ki
105900±180 nM
Citation
 Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9738628 Publication Date 8/22/2017 
Target
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Homo sapiens (Human)
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Inhibitor
Name:
BDBM213752
Synonyms:
US9284299, 11 | US9284299, 3 | US9738628, Compound 11
Type:
Small organic molecule
Emp. Form.:
C9H7N5O2S
Mol. Mass.:
249.249
SMILES:
On1nnc2cc(Cc3noc(=S)[nH]3)ccc12
Structure:
Search PDB for entries with ligand similarity: