Reaction Details Report a problem with these data
Target
Catenin beta-1 [138-686]
Ligand
BDBM50436058
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assay
Ki
24390±740 nM
Citation
 Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9738628 Publication Date 8/22/2017 
Target
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Homo sapiens (Human)
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Inhibitor
Name:
BDBM50436058
Synonyms:
CHEMBL254381 | PNU-74654 | US9738628, Compound PNU-74654
Type:
Small organic molecule
Emp. Form.:
C19H16N2O3
Mol. Mass.:
320.3419
SMILES:
Cc1ccc(\C=N\NC(=O)c2ccccc2Oc2ccccc2)o1
Structure:
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