Reaction Details Report a problem with these data
Target
Glucocorticoid receptor
Ligand
BDBM141377
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
IC50
2.15±n/a nM
Citation
 Berger, M; Rehwinkel, H; Dahmen, J; Eriksson, A; Hansson, T; Hossain, N; Klingstedt, PT; Lepisto, M; Nilsson, S; Hemmerling, M; Edman, K Phenyl and benzodioxinyl substituted indazoles derivatives US Patent  US9738632 Publication Date 8/22/2017 
Target
Name:
Glucocorticoid receptor
Synonyms:
GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:
Enzyme
Mol. Mass.:
85656.87
Organism:
Homo sapiens (Human)
Description:
P04150
Residue:
777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
  
Inhibitor
Name:
BDBM141377
Synonyms:
US8916600, 11 | US9738632, Example 11
Type:
Small organic molecule
Emp. Form.:
C32H34F2N4O6
Mol. Mass.:
608.6324
SMILES:
CC[C@@H](O)CNC(=O)c1cccc(c1)-n1ncc2cc(O[C@@H]([C@H](C)NC(=O)C(C)(F)F)c3ccc4COCOc4c3)ccc12 |r|
Structure:
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