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Target
Isoform Beta of cGMP-dependent protein kinase 1 [1-351,G182E]
Ligand
BDBM65505
Substrate
n/a
Meas. Tech.
Microfluidic Mobility-Shift Assay
pH
7±n/a
EC50
5.8±0.4 nM
Comments
extracted
Citation
 Campbell, JC; Henning, P; Franz, E; Sankaran, B; Herberg, FW; Kim, C Structural Basis of Analog Specificity in PKG I and II. ACS Chem Biol 12:2388-2398 (2017) [PubMed]  Article 
Target
Name:
Isoform Beta of cGMP-dependent protein kinase 1 [1-351,G182E]
Synonyms:
KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | cGMP-dependent protein kinase 1 [1-351,G182E] | hPKG 1 beta (aa 1-351) (G182E)
Type:
Protein
Mol. Mass.:
39744.76
Organism:
Homo sapiens (Human)
Description:
Q13976-2 (1-351) (G182E)
Residue:
351
Sequence:
MGTLRDLQYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFEELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAY
  
Inhibitor
Name:
BDBM65505
Synonyms:
PET-cGMP
Type:
Small organic molecule
Emp. Form.:
C18H16N5O7P
Mol. Mass.:
445.3227
SMILES:
O[C@@H]1[C@@H]2OP(O)(=O)OC[C@H]2O[C@H]1n1cnc2c1[nH]c1nc(cn1c2=O)-c1ccccc1
Structure:
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