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Target
Intermediate conductance calcium-activated potassium channel protein 4
Ligand
BDBM200865
Substrate
n/a
Meas. Tech.
KCa3.1 Assay
IC50
240±0 nM
Citation
 Burke, MJ; McKibben, B; Tschantz, MA Fused thiazin-3-ones as KCA3.1 inhibitors US Patent  US9533999 Publication Date 1/3/2017 
Target
Name:
Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:
IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:
PROTEIN
Mol. Mass.:
47723.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361891
Residue:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
  
Inhibitor
Name:
BDBM200865
Synonyms:
US9533999, i-21
Type:
Small organic molecule
Emp. Form.:
C16H12BrF3N2O3S
Mol. Mass.:
449.242
SMILES:
CC(N1C(=O)CS(=O)(=O)c2ncc(Br)cc12)c1cccc(c1)C(F)(F)F
Structure:
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