Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM336227
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
3700±n/a nM
Citation
 Linschoten, M Kallikrein 7 inhibitors US Patent  US9744148 Publication Date 8/29/2017 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM336227
Synonyms:
US9744148, 96
Type:
Small organic molecule
Emp. Form.:
C26H25FN2O4
Mol. Mass.:
448.4861
SMILES:
CC(C)C(OC(=O)C(NC(=O)c1ccccc1)c1ccccc1)C(=O)Nc1ccc(F)cc1
Structure:
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