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TargetTyrosine-protein kinase Mer
LigandBDBM336284
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 55±n/a nM
Citation Wang, XLiu, JYang, CZhang, WFrye, SKireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Mer
Name:Tyrosine-protein kinase Mer
Synonyms:MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK
Type:PROTEIN
Mol. Mass.:110234.77
Organism:Homo sapiens (Human)
Description:ChEMBL_1498723
Residue:999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
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  Blast E-value cutoff:
BDBM336284
NameBDBM336284
Synonyms:US9744172, Compound UNC1067A
TypeSmall organic molecule
Emp. Form.C23H27F3N6O2
Mol. Mass.476.4947
SMILESO[C@H]1CCC(CC1)n1nc(-c2ccc(cc2)N2CCOCC2)c2cnc(NCC(F)(F)F)nc12 |r,wD:1.0,(4.59,-8.68,;4.19,-7.2,;5.28,-6.11,;4.88,-4.62,;3.39,-4.22,;2.3,-5.31,;2.7,-6.8,;2.99,-2.73,;3.9,-1.49,;2.99,-.24,;3.39,1.25,;4.88,1.64,;5.28,3.13,;4.19,4.22,;2.7,3.82,;2.3,2.33,;4.59,5.71,;6.08,6.11,;6.47,7.59,;5.38,8.68,;3.9,8.29,;3.5,6.8,;1.53,-.72,;.19,.05,;-1.14,-.72,;-1.14,-2.26,;-2.47,-3.03,;-3.81,-2.26,;-5.14,-3.03,;-5.14,-4.57,;-6.47,-3.8,;-6.47,-2.26,;.19,-3.03,;1.53,-2.26,)|
Structure
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