Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosine-protein kinase Mer
LigandBDBM336316
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 20000±n/a nM
Citation Wang, XLiu, JYang, CZhang, WFrye, SKireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Mer
Name:Tyrosine-protein kinase Mer
Synonyms:MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK
Type:PROTEIN
Mol. Mass.:110234.77
Organism:Homo sapiens (Human)
Description:ChEMBL_1498723
Residue:999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM336316
NameBDBM336316
Synonyms:US9744172, Compound UNC00000345A
TypeSmall organic molecule
Emp. Form.C24H33N7O
Mol. Mass.435.5651
SMILESNC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCCN4CCOCC4)nc23)CC1 |(9.24,-4.67,;7.75,-4.27,;6.66,-5.36,;5.18,-4.96,;4.78,-3.48,;3.29,-3.08,;2.89,-1.59,;3.8,-.35,;2.89,.9,;3.29,2.39,;4.78,2.79,;5.18,4.27,;4.09,5.36,;2.6,4.96,;2.2,3.48,;1.43,.42,;.09,1.19,;-1.24,.42,;-1.24,-1.12,;-2.57,-1.89,;-3.91,-1.12,;-5.24,-1.89,;-6.57,-1.12,;-6.57,.42,;-7.91,1.19,;-9.24,.42,;-9.24,-1.12,;-7.91,-1.89,;.09,-1.89,;1.43,-1.12,;5.87,-2.39,;7.36,-2.79,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a