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TargetTyrosine-protein kinase Mer
LigandBDBM336421
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50<10±n/a nM
Citation Wang, XLiu, JYang, CZhang, WFrye, SKireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Mer
Name:Tyrosine-protein kinase Mer
Synonyms:MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK
Type:PROTEIN
Mol. Mass.:110234.77
Organism:Homo sapiens (Human)
Description:ChEMBL_1498723
Residue:999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
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  Blast E-value cutoff:
BDBM336421
NameBDBM336421
Synonyms:US9744172, Compound UNC1170A
TypeSmall organic molecule
Emp. Form.C27H37N7O2
Mol. Mass.491.6284
SMILESCCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCOCC1 |r,wD:16.16,(-8.68,-4.25,;-7.35,-3.48,;-6.01,-4.25,;-4.68,-3.48,;-3.34,-4.25,;-2.01,-3.48,;-2.01,-1.94,;-.68,-1.17,;.66,-1.94,;2.12,-1.46,;3.03,-2.71,;2.12,-3.95,;2.52,-5.44,;4.06,-5.44,;4.83,-4.11,;6.37,-4.11,;7.14,-5.44,;8.68,-5.44,;6.37,-6.77,;4.83,-6.77,;.66,-3.48,;-.68,-4.25,;2.52,.03,;4.01,.43,;4.41,1.91,;3.32,3,;1.83,2.6,;1.43,1.12,;3.72,4.49,;2.63,5.58,;5.2,4.89,;6.29,3.8,;7.78,4.2,;8.18,5.68,;7.09,6.77,;5.6,6.38,)|
Structure
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