Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosine-protein kinase Mer
LigandBDBM336495
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 55±n/a nM
Citation Wang, XLiu, JYang, CZhang, WFrye, SKireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Mer
Name:Tyrosine-protein kinase Mer
Synonyms:MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK
Type:PROTEIN
Mol. Mass.:110234.77
Organism:Homo sapiens (Human)
Description:ChEMBL_1498723
Residue:999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM336495
NameBDBM336495
Synonyms:US9744172, Compound UNC1323A
TypeSmall organic molecule
Emp. Form.C34H45N7O4S
Mol. Mass.647.831
SMILESCCCCCNC(=O)c1ccc(cc1)N(C)S(=O)(=O)c1ccc(cc1)-c1nn(C2CC[C@H](O)CC2)c2nc(NCCCC)ncc12 |r,wD:31.33,(10.57,13.2,;10.17,11.71,;8.68,11.31,;8.28,9.83,;6.8,9.43,;6.4,7.94,;4.91,7.54,;3.82,8.63,;4.51,6.05,;5.6,4.96,;5.2,3.48,;3.71,3.08,;2.62,4.17,;3.02,5.66,;3.31,1.59,;4.4,.5,;1.83,1.19,;.29,1.19,;1.06,2.53,;1.43,-.3,;2.52,-1.38,;2.12,-2.87,;.63,-3.27,;-.46,-2.18,;-.06,-.69,;.23,-4.76,;1.14,-6,;.23,-7.25,;.63,-8.74,;2.12,-9.14,;2.52,-10.62,;1.43,-11.71,;1.83,-13.2,;-.06,-11.31,;-.46,-9.83,;-1.23,-6.77,;-2.57,-7.54,;-3.9,-6.77,;-5.23,-7.54,;-6.57,-6.77,;-7.9,-7.54,;-9.23,-6.77,;-10.57,-7.54,;-3.9,-5.23,;-2.57,-4.46,;-1.23,-5.23,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a