Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM200843
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
28.5±0 nM
Comments
extracted
Citation
 Gray, DL; Zhang, L; Brodney, MA; Green, ME; Subramanyam, C Substituted 1,7-naphthyridines as dopamine D1 ligands US Patent  US9540352 Publication Date 1/10/2017 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM200843
Synonyms:
1,5-dimethyl-6-[2-methyl-4-(1,7-naphthyridin-8-yloxy)phenyl]pyrimidine-2,4(1h,3h)-dione (1) | US9540352, example 1
Type:
Small organic molecule
Emp. Form.:
C21H18N4O3
Mol. Mass.:
374.3926
SMILES:
Cc1cc(Oc2nccc3cccnc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C |(-14.67,-17.78,;-14.67,-19.32,;-16,-20.09,;-16,-21.63,;-17.34,-22.4,;-17.34,-23.94,;-16,-24.71,;-16,-26.25,;-17.34,-27.02,;-18.67,-26.25,;-20,-27.02,;-21.34,-26.25,;-21.34,-24.71,;-20,-23.94,;-18.67,-24.71,;-14.67,-22.4,;-13.33,-21.63,;-13.33,-20.09,;-12,-19.32,;-12,-17.78,;-13.33,-17.01,;-10.67,-17.01,;-10.67,-15.47,;-9.33,-17.78,;-9.33,-19.32,;-8,-20.09,;-10.67,-20.09,;-10.67,-21.63,)|
Structure:
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