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Target
D(1A) dopamine receptor
Ligand
BDBM200989
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
334±0 nM
Comments
extracted
Citation
 Gray, DL; Zhang, L; Brodney, MA; Green, ME; Subramanyam, C Substituted 1,7-naphthyridines as dopamine D1 ligands US Patent  US9540352 Publication Date 1/10/2017 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM200989
Synonyms:
1-[4-(3,5-dimethyl-6-oxo-1,6- 4dihydropyridazin--yl)-3-methylphenoxy] isoquinoline-7-carbonitrile | US9540352, example 13
Type:
Small organic molecule
Emp. Form.:
C23H18N4O2
Mol. Mass.:
382.4146
SMILES:
Cc1cc(Oc2nccc3ccc(cc23)C#N)ccc1-c1c(C)n[nH]c(=O)c1C |(2,3.47,;2,1.93,;.67,1.15,;.67,-.38,;-.67,-1.15,;-.67,-2.69,;.67,-3.47,;.67,-5,;-.67,-5.78,;-2,-5.01,;-3.33,-5.78,;-4.67,-5.01,;-4.67,-3.47,;-3.33,-2.7,;-2,-3.47,;-6,-2.7,;-7.34,-1.93,;2,-1.15,;3.33,-.38,;3.33,1.15,;4.67,1.93,;6,1.15,;6,-.38,;7.34,1.93,;7.34,3.47,;6,4.23,;6,5.78,;4.67,3.47,;3.33,4.23,)|
Structure:
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