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TargetNuclear receptor ROR-gamma
LigandBDBM332517
Substrate/Competitorn/a
Meas. Tech.Biochemical TR-FRET Assay
IC50 5.00±n/a nM
Citation Barr, KJBienstock, CEMaclean, JKZhang, HBeresis, RTZhang, DAnthony, NJLapointe, BTTian, Y 4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof US Patent US9745265 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor
Type:PROTEIN
Mol. Mass.:58133.31
Organism:Mus musculus
Description:ChEMBL_103664
Residue:516
Sequence:
MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
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BDBM332517
NameBDBM332517
Synonyms:4-(1-(2-chloro-6- cyclopropylbenzoyl)-1H- indazol-3-yl)-3,5- difluorobenzoic acid | US10196354, Example 33B | US9745265, 33B
TypeSmall organic molecule
Emp. Form.C24H15ClF2N2O3
Mol. Mass.452.837
SMILESOC(=O)c1cc(F)c(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3ccccc23)c(F)c1 |(2.72,7.05,;1.23,6.65,;.14,7.74,;.83,5.16,;-.66,4.77,;-1.06,3.28,;-2.54,2.88,;.03,2.19,;-.36,.7,;.54,-.54,;-.36,-1.79,;.03,-3.28,;-1.06,-4.37,;1.52,-3.68,;2.61,-2.59,;2.21,-1.1,;4.1,-2.99,;4.5,-4.47,;3.41,-5.56,;1.92,-5.16,;.83,-6.25,;-.66,-6.65,;.43,-7.74,;-1.83,-1.31,;-3.16,-2.08,;-4.5,-1.31,;-4.5,.23,;-3.16,1,;-1.83,.23,;1.52,2.59,;2.61,1.5,;1.92,4.08,)|
Structure
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