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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM336522
Substrate
n/a
IC50
10000±n/a nM
Citation
 Ali, A; Lo, MM; Metzger, E; Yin, L; Hartmann, R; Hu, Q; Heim, R; Zimmer, C Indoline compounds as aldosterone synthase inhibitors US Patent  US9745282 Publication Date 8/29/2017 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
  
Inhibitor
Name:
BDBM336522
Synonyms:
1-(6-fluoro-5-(5- fluoropyridin-3- yl)indolin-1- yl)ethanone | US9745282, 48
Type:
Small organic molecule
Emp. Form.:
C15H12F2N2O
Mol. Mass.:
274.2654
SMILES:
CC(=O)N1CCc2cc(c(F)cc12)-c1cncc(F)c1
Structure:
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