Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM336760
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
8194±n/a nM
Citation
 Kuduk, SDSkudlarek, JW 2-pyridyloxy-4-ether orexin receptor antagonists US Patent  US9745284 Publication Date 8/29/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM336760
Synonyms:
2-cyclopropyl- 6-methoxy-3- ({(2R,5R)-5-[(4- methoxypyridin- 2-yl)oxy]-2- methylpiperidin-1- yl}carbonyl) pyridine | US9745284, 21
Type:
Small organic molecule
Emp. Form.:
C22H27N3O4
Mol. Mass.:
397.4675
SMILES:
COc1ccnc(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccc(OC)nc2C2CC2)c1
Structure:
Search PDB for entries with ligand similarity: