Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM336762
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
10000±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW 2-pyridyloxy-4-ether orexin receptor antagonists US Patent  US9745284 Publication Date 8/29/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM336762
Synonyms:
2-{[(3R,6R)-1- {[4-methoxy-2- (2H-1,2,3-triazol- 2-yl)phenyl] carbonyl}-6- methylpiperidin- 3-yl]oxy}-4-(1- methylethoxy) pyridine | US9745284, 24
Type:
Small organic molecule
Emp. Form.:
C24H29N5O4
Mol. Mass.:
451.5182
SMILES:
COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2cc(OC(C)C)ccn2)c(c1)-n1nccn1
Structure:
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