Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM336771
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
10000±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW 2-pyridyloxy-4-ether orexin receptor antagonists US Patent  US9745284 Publication Date 8/29/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM336771
Synonyms:
2-{[(2R,5R)-5-{[4-(2,2- difluoroethoxy)pyridin-2- yl]oxy}-2-methylpiperidin-1- yl]carbonyl}-3-(2H-1,2,3- triazol-2-yl)pyridine | US9745284, 33
Type:
Small organic molecule
Emp. Form.:
C21H22F2N6O3
Mol. Mass.:
444.4346
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ncccc1-n1nccn1)Oc1cc(OCC(F)F)ccn1
Structure:
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