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TargetOrexin receptor type 2
LigandBDBM336799
Substrate/Competitorn/a
Meas. Tech.FLIPR Ca2+ Flux Assay
IC50 55.0±n/a nM
Citation Kuduk, SDSkudlarek, JW 2-pyridyloxy-4-ether orexin receptor antagonists US Patent US9745284 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Orexin receptor type 2
Name:Orexin receptor type 2
Synonyms:HCRTR2 | Hypocretin receptor type 2 | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:Protein
Mol. Mass.:50710.53
Organism:Homo sapiens (Human)
Description:O43614
Residue:444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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  Blast E-value cutoff:
BDBM336799
NameBDBM336799
Synonyms:2-{[(3R,6R)-6-methyl-1- {[2-(2H-1,2,3-triazol-2- yl)thiophen-3-yl]carbonyl} piperidin-3-yl]oxy}-4- (2,2,2-trifluoroethoxy) pyridine | US9745284, 63
TypeSmall organic molecule
Emp. Form.C20H20F3N5O3S
Mol. Mass.467.465
SMILESC[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)Oc1cc(OCC(F)(F)F)ccn1
Structure
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