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Reaction Details
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TargetCoagulation factor VII
LigandBDBM13581
Substrate/CompetitorBDBM13553
Meas. Tech.Serine Protease Inhibition Assay
pH7.8±n/a
Temperature295.15±n/a K
Ki 380±n/a nM
Citation Groebke Zbinden, KBanner, DWAckermann, JD'Arcy, AKirchhofer, DJi, YHTschopp, TBWallbaum, SWeber, L Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett15:817-22 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Coagulation factor VII
Name:Thrombin and coagulation factor VII
Synonyms:Eptacog alfa | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM13581
NameBDBM13581
Synonyms:4-({[4-(benzyloxy)-2-methanesulfonamido-5-methoxyphenyl]methyl}amino)benzene-1-carboximidamide | benzylamine 7
TypeSmall organic molecule
Emp. Form.C23H26N4O4S
Mol. Mass.454.542
SMILESCOc1cc(CNc2ccc(cc2)C(N)=N)c(NS(C)(=O)=O)cc1OCc1ccccc1
Structure
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BDBM13553
NameBDBM13553
Synonyms:(2S)-5-carbamimidamido-2-{2-[(2R)-2-methanesulfonamido-3-phenylpropanamido]acetamido}-N-(4-nitrophenyl)pentanamide; acetic acid | Chromozym tPA | N-Methylsulfonyl-D-Phe-Gly-Arg-4-nitranilide acetate
TypeSmall organic molecule
Emp. Form.C24H32N8O7S
Mol. Mass.576.625
SMILESCS(=O)(=O)N[C@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure
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