Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTrypsin
LigandBDBM13576
Substrate/CompetitorBDBM13574
Meas. Tech.Serine Protease Inhibition Assay
Ki 2000±n/a nM
Citation Groebke Zbinden, KBanner, DWAckermann, JD'Arcy, AKirchhofer, DJi, YHTschopp, TBWallbaum, SWeber, L Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett15:817-22 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Trypsin
Name:Trypsin I
Synonyms:Beta-Trypsin | Cationic trypsin | Trypsin I
Type:Enzyme
Mol. Mass.:25790.52
Organism:Bos taurus (bovine)
Description:P00760
Residue:246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM13576
NameBDBM13576
Synonyms:N-benzyl-2-[(4-carbamimidoylphenyl)amino]-2-(3,4-diethoxyphenyl)acetamide | phenylglycine amide compound 2
TypeSmall organic molecule
Emp. Form.C26H30N4O3
Mol. Mass.446.5414
SMILESCCOc1ccc(cc1OCC)C(Nc1ccc(cc1)C(N)=N)C(=O)NCc1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM13574
NameBDBM13574
Synonyms:(2S)-6-amino-2-[(2S)-2-[(2R)-2-amino-3-methylbutanamido]-4-methylpentanamido]-N-(4-nitrophenyl)hexanamide dihydrochloride | Chromogenic Substrate S-2251 | H-D-Valyl-L-leucyl-L-lysine-p-Nitroaniline dihydrochloride
TypeSmall organic molecule
Emp. Form.C23H38N6O5
Mol. Mass.478.585
SMILESCC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: