Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
LigandBDBM337251
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50 6.00±n/a nM
Citation Zorn, LEis, KSchulze, VSülzle, DPuehler, FLienau, PBömer, UPetersen, KHägebarth, A Amidoimidazopyridazines as MKNK-1 kinase inhibitors US Patent US9745304 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
Name:MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:48837.99
Organism:Homo sapiens (Human)
Description:aa: 1-424 and T344D
Residue:442
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM337251
NameBDBM337251
Synonyms:N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6-yl]- 3-(1-methyl-1H-pyrazol-4- yl)propanamide | US9745304, Example 20
TypeSmall organic molecule
Emp. Form.C21H18N6O2
Mol. Mass.386.4066
SMILESCn1cc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)cn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a