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TargetMAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
LigandBDBM337241
Substrate/Competitorn/a
Meas. Tech.Kinase High ATP Assay
IC50 36.0±n/a nM
Citation Zorn, LEis, KSchulze, VSülzle, DPuehler, FLienau, PBömer, UPetersen, KHägebarth, A Amidoimidazopyridazines as MKNK-1 kinase inhibitors US Patent US9745304 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
Name:MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:48837.99
Organism:Homo sapiens (Human)
Description:aa: 1-424 and T344D
Residue:442
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKS
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  Blast E-value cutoff:
BDBM337241
NameBDBM337241
Synonyms:N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide | US9745304, Example 10
TypeSmall organic molecule
Emp. Form.C19H12N6O4
Mol. Mass.388.3364
SMILESO=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cc(=O)[nH]c(=O)[nH]1
Structure
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n/a