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TargetMitogen-activated protein kinase 1
LigandBDBM272787
Substrate/Competitorn/a
Meas. Tech.IMAP-FP assay
IC50 21.0±n/a nM
Citation Lim, JHuang, XFerguson, RDZhou, WBoyce, CWSiliphaivanh, PWitter, DJMaletic, MMKozlowski, JAWilson, KJ Compounds that are ERK inhibitors US Patent US9745307 Publication Date 8/29/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM272787
NameBDBM272787
Synonyms:6-((R)-1-phenylethyl)-3-((tetrahydrofuran-3-yl)oxy)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one | US10065967, Example 38 | US9745307, Example 38
TypeSmall organic molecule
Emp. Form.C21H22N4O3
Mol. Mass.378.4244
SMILESC[C@@H](N1Cc2cc3c(OC4CCOC4)n[nH]c3cc2NC1=O)c1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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