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TargetDopamine D1 receptor
LigandBDBM337363
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 76.8±n/a nM
Citation Gray, DLZhang, LBrodney, MADavoren, JEEfremov, IVGreen, MEO Neil, SVRogers, BN Heterocyclic compounds and their use as dopamine D1 ligands US Patent US9745317 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Dopamine D1 receptor
Name:Dopamine D1 and D2 receptor
Synonyms:DA D1 receptor | DOPAMINE D1 | DRD1 | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:Enzyme
Mol. Mass.:49303.43
Organism:Homo sapiens (Human)
Description:P21728
Residue:446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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  Blast E-value cutoff:
BDBM337363
NameBDBM337363
Synonyms:4-[4-(4,6-Dimethylpyrimidin-5-yl)-3-methylphenoxy]-2,3-dihydrofuro[3,2-c]pyridine (1) | US9745317, 1
TypeSmall organic molecule
Emp. Form.C20H19N3O2
Mol. Mass.333.3838
SMILESCc1cc(Oc2nccc3OCCc23)ccc1-c1c(C)ncnc1C |(-13.7,-3.62,;-13.7,-5.16,;-15.03,-5.93,;-15.03,-7.47,;-16.36,-8.24,;-16.36,-9.78,;-15.03,-10.55,;-15.03,-12.09,;-16.36,-12.86,;-17.7,-12.09,;-19.16,-12.57,;-20.07,-11.32,;-19.16,-10.08,;-17.7,-10.55,;-13.7,-8.24,;-12.36,-7.47,;-12.36,-5.93,;-11.03,-5.16,;-9.7,-5.93,;-9.7,-7.47,;-8.36,-5.16,;-8.36,-3.62,;-9.7,-2.85,;-11.03,-3.62,;-12.36,-2.85,)|
Structure
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