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TargetDopamine D1 receptor
LigandBDBM337377
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 18.1±n/a nM
Citation Gray, DLZhang, LBrodney, MADavoren, JEEfremov, IVGreen, MEO Neil, SVRogers, BN Heterocyclic compounds and their use as dopamine D1 ligands US Patent US9745317 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Dopamine D1 receptor
Name:Dopamine D1 and D2 receptor
Synonyms:DA D1 receptor | DOPAMINE D1 | DRD1 | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:Enzyme
Mol. Mass.:49303.43
Organism:Homo sapiens (Human)
Description:P21728
Residue:446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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  Blast E-value cutoff:
BDBM337377
NameBDBM337377
Synonyms:4,6-Dimethyl-5-[2-methyl-4-(1,2,3,4-tetrahydro-1,6-naphthyridin-5-yloxy)phenyl]pyridazin-3(2H)-one (15) | US9745317, 15
TypeSmall organic molecule
Emp. Form.C33H36N4O3
Mol. Mass.536.6639
SMILESCc1cc(Oc2nccc3N(Cc4ccccc4)CCCc23)ccc1-c1c(C)nn(C2CCCCO2)c(=O)c1C |(9.76,22.28,;9.76,20.74,;8.43,19.97,;8.43,18.43,;7.1,17.66,;7.1,16.12,;8.43,15.35,;8.43,13.81,;7.1,13.04,;5.76,13.81,;4.43,13.04,;4.43,11.5,;5.76,10.73,;5.76,9.19,;7.1,8.42,;8.43,9.19,;8.43,10.73,;7.1,11.5,;3.09,13.81,;3.09,15.35,;4.43,16.12,;5.76,15.35,;9.76,17.66,;11.1,18.43,;11.1,19.97,;12.43,20.74,;13.76,19.97,;13.76,18.43,;15.1,20.74,;15.1,22.28,;16.43,23.05,;16.43,24.59,;17.77,25.36,;19.1,24.59,;19.1,23.05,;17.77,22.28,;13.76,23.05,;13.76,24.59,;12.43,22.28,;11.1,23.05,)|
Structure
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