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TargetDopamine D1 receptor
LigandBDBM337379
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 28.9±n/a nM
Citation Gray, DLZhang, LBrodney, MADavoren, JEEfremov, IVGreen, MEO Neil, SVRogers, BN Heterocyclic compounds and their use as dopamine D1 ligands US Patent US9745317 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Dopamine D1 receptor
Name:Dopamine D1 and D2 receptor
Synonyms:DA D1 receptor | DOPAMINE D1 | DRD1 | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:Enzyme
Mol. Mass.:49303.43
Organism:Homo sapiens (Human)
Description:P21728
Residue:446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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  Blast E-value cutoff:
BDBM337379
NameBDBM337379
Synonyms:4-[4-(4,6-Dimethylpyrimidin-5-yl)-3-methylphenoxy]-2,3-dihydrofuro[3,2-c]pyridin-3-ol (17) | US9745317, 17
TypeSmall organic molecule
Emp. Form.C33H53P
Mol. Mass.480.7477
SMILESCC(C)c1cc(C(C)C)c(c(c1)C(C)C)-c1c(C)c(C)c(C)c(C)c1P(C(C)(C)C)C(C)(C)C |(5.4,8.84,;3.91,9.24,;3.52,10.73,;2.83,8.15,;1.34,8.55,;.25,7.46,;-1.24,7.86,;-1.64,9.35,;-2.33,6.77,;.65,5.98,;2.14,5.58,;3.22,6.67,;2.53,4.09,;4.02,3.69,;1.44,3,;-2.31,2.83,;-1.54,1.5,;0,1.5,;-2.31,.17,;-1.54,-1.17,;-3.85,.17,;-4.62,-1.17,;-4.62,1.5,;-6.16,1.5,;-3.85,2.83,;-4.62,4.17,;-6.16,4.17,;-6.93,2.83,;-6.93,5.5,;-7.7,4.17,;-3.85,5.5,;-2.31,5.5,;-4.62,6.83,;-3.08,6.83,)|
Structure
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