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TargetDopamine D1 receptor
LigandBDBM337380
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 52.1±n/a nM
Citation Gray, DLZhang, LBrodney, MADavoren, JEEfremov, IVGreen, MEO Neil, SVRogers, BN Heterocyclic compounds and their use as dopamine D1 ligands US Patent US9745317 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Dopamine D1 receptor
Name:Dopamine D1 and D2 receptor
Synonyms:DA D1 receptor | DOPAMINE D1 | DRD1 | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:Enzyme
Mol. Mass.:49303.43
Organism:Homo sapiens (Human)
Description:P21728
Residue:446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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  Blast E-value cutoff:
BDBM337380
NameBDBM337380
Synonyms:US9745317, 18
TypeSmall organic molecule
Emp. Form.C21H18N4O2
Mol. Mass.358.3932
SMILESCc1cc(Oc2nccc3OCCc23)ccc1-c1c(C)ncc2nccn12 |(-.05,4.23,;-.05,2.69,;-1.39,1.92,;-1.39,.38,;-2.72,-.39,;-2.72,-1.93,;-1.39,-2.7,;-1.39,-4.24,;-2.72,-5.01,;-4.06,-4.24,;-5.52,-4.71,;-6.43,-3.47,;-5.52,-2.22,;-4.06,-2.7,;-.05,-.38,;1.28,.38,;1.28,1.92,;2.61,2.7,;2.61,4.24,;1.28,5.01,;3.95,5,;5.28,4.24,;5.28,2.7,;6.43,1.66,;5.8,.26,;4.27,.42,;3.95,1.93,)|
Structure
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