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TargetDopamine D1 receptor
LigandBDBM337382
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 446±n/a nM
Citation Gray, DLZhang, LBrodney, MADavoren, JEEfremov, IVGreen, MEO Neil, SVRogers, BN Heterocyclic compounds and their use as dopamine D1 ligands US Patent US9745317 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Dopamine D1 receptor
Name:Dopamine D1 and D2 receptor
Synonyms:DA D1 receptor | DOPAMINE D1 | DRD1 | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:Enzyme
Mol. Mass.:49303.43
Organism:Homo sapiens (Human)
Description:P21728
Residue:446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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  Blast E-value cutoff:
BDBM337382
NameBDBM337382
Synonyms:US9745317, 20
TypeSmall organic molecule
Emp. Form.C20H20N4O
Mol. Mass.332.399
SMILESCc1cc(Oc2ncnc3CCCc23)ccc1-c1c(C)ncnc1C |(.52,4.23,;.52,2.69,;-.82,1.92,;-.82,.38,;-2.15,-.39,;-2.15,-1.93,;-.82,-2.7,;-.82,-4.24,;-2.15,-5.01,;-3.48,-4.24,;-4.95,-4.71,;-5.85,-3.47,;-4.95,-2.22,;-3.48,-2.7,;.52,-.38,;1.85,.38,;1.85,1.92,;3.19,2.7,;3.19,4.24,;1.85,5.01,;4.52,5,;5.85,4.24,;5.85,2.7,;4.52,1.93,;4.52,.39,)|
Structure
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