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TargetBeta-secretase 2
LigandBDBM337562
Substrate/Competitorn/a
Meas. Tech.Time-Resolved Endpoint Proteolysis Assay
Ki 202±n/a nM
Citation Dai, XCumming, JNScott, JDLiu, HPalani, A Iminothiadiazepane dioxide compounds as BACE inhibitors, compositions, and their use US Patent US9745324 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 2
Name:Beta-secretase (BACE)
Synonyms:ASP1 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | Beta secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:Protein
Mol. Mass.:56171.20
Organism:Homo sapiens (Human)
Description:Q9Y5Z0
Residue:518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM337562
NameBDBM337562
Synonyms:US9745324, 31
TypeSmall organic molecule
Emp. Form.C20H22F4N6O3S
Mol. Mass.502.486
SMILESCN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ncc(cn2)C(F)(F)F)ccc1F |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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