Reaction Details Report a problem with these data
Target
Flap endonuclease 1
Ligand
BDBM283229
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
<1±n/a nM
Comments
Zero 01/04/2022
Citation
 Bacani, GM; Eccles, W; Fitzgerald, AE; Goldberg, SD; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Lee-Dutra, A; Liu, J; McClure, KJ; Meduna, SP; Pippel, DJ; Rosen, MD; Sales, ZS Flap modulators US Patent  US9745328 Publication Date 8/29/2017 
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM283229
Synonyms:
4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-(3- hydroxy-1,1-dimethylpropyl)biphenyl-2- sulfonamide | US9745328, Compound 102 | US9884878, Compound 102
Type:
Small organic molecule
Emp. Form.:
C21H23FN4O3S
Mol. Mass.:
430.496
SMILES:
CC(C)(CCO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Structure:
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