Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM337708
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
28.0±n/a nM
Citation
Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M Substituted uracils and use thereof US Patent US9751843 Publication Date 9/5/2017
More Info.:
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
Inhibitor
Name:
BDBM337708
Synonyms:
3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1-[4-(5-oxopyrrolidin-2-yl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid | US9751843, 81
Type:
Small organic molecule
Emp. Form.:
C24H20F3N3O5
Mol. Mass.:
487.4279
SMILES:
Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)C3CCC(=O)N3)c2=O)C(O)=O)cccc1C(F)(F)F