Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM337758
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
17.0±n/a nM
Citation
Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M Substituted uracils and use thereof US Patent US9751843 Publication Date 9/5/2017
More Info.:
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
Inhibitor
Name:
BDBM337758
Synonyms:
1-[3-Chloro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3-[2-chloro-3-(trifluoromethyl)benzyl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid | US9751843, 151
Type:
Small organic molecule
Emp. Form.:
C22H14Cl2F3N3O6
Mol. Mass.:
544.264
SMILES:
OC(=O)c1cn(-c2ccc(N3CCOC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O